Our researchers
Who are they?
Active, dynamic members
French leaders with expertise in the cardiovascular field (cardiologists, nephrologists, intensive care anaesthetists, emergency physicians, internists, epidemiologists, vascular physicians, geriatricians, cardiac and vascular surgeons, methodologists, basic researchers, computer scientists, engineers, as well as an ARO (Academic Research Organisation), haemodialysis centres, heart failure networks, the Biomedicine Agency.
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- Malika SMAIL-TABBONE is an Associate Professor at the University of Lorraine. She holds a doctorate in computer science and is a member of the LORIA computer science laboratory, affiliated to the CNRS and Inria. She teaches the principles and techniques of databases and data mining in several university courses.
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- Stéphanie Grojean General Manager of the Research and Training DepartmentForce Foundation. Following a PhD in Neuroscience in 2002, I joined the CIC Purithématique as project manager until 2008. The experience acquired during these 6 years enabled me to create an academic CRO (Clinical research organisation) under the aegis of a public utility foundation, the Force Foundation.
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- Benjamin Glenn CHOUSTERMAN is a MCU-PH in the polyvalent surgical resuscitation service of the Department of Anaesthesia-Resuscitation at Lariboisière Hospital. His clinical activity is focused on the peri-operative course of heavy surgery and severe neurological injuries. He is the head of an ATIP-Avenir team in Inserm Unit 942 and leads a research team on immuno-inflammation in the critical patient. He is the principal investigator of several clinical trials including the Rasbu-Sepsis (PHRC 2019) and LEVOSAH (APHP - Orion Pharma) studies.
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- Professor François Roubille, head of the ICU and the heart failure team of the MONTPELLIER University Hospital. Former president of the USIC group, in charge of the research group of the GICC group of the French Society of Cardiology. Territorial animation of the research at the CHU of Montpellier.
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- Guillaume Geri is a professor of intensive care medicine at the Ambroise Paré Hospital in Boulogne-Billancourt. He works on the long-term outcome of patients leaving intensive care alive and is particularly interested in the factors favouring the occurrence of acute renal failure and the prognosis of its long-term outcome. He is the coordinating investigator of the PREDICT study, a multi-centre observational study aimed at following patients with acute renal failure in intensive care. His other area of interest is the management of patients with cardiac arrest in the ICU, particularly with regard to organ replacement in this specific subgroup of patients.
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- Antoine Kimmoun Intensivist and resuscitator. Research interests include beta-adrenergic stimulation during shock and acute heart failure (specifically cardiogenic shock). Affiliated with the U1116 and U942 units
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- Professor Romain Eschalier completed his medical studies in Clermont-Ferrand, Nancy and the IHU in Bordeaux. He works at the Cardiology and Cardiovascular Diseases Department of the Clermont-Ferrand University Hospital and is a teacher-researcher at the Clermont-Auvergne University. He coordinates several clinical studies on the medical and electrical management of heart failure. He is a member of the publishing company "Stimuprat" (development of medical and paramedical training), but also of various learned societies since 2009 (ESC, EHRA, SFC). He is involved in the functioning and the scientific committee of Cardiauvergne for the coordination of care for the ambulatory management of heart failure patients in Auvergne. One of his current themes concerns the fate of patients with left bundle branch block in post-TAVI.
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- Romain Boulestreau - Currently a cardiologist at the Bordeaux University Hospital, I joined INI-CRCT in 2020 when I started to conduct multicentre research projects. I am a cardiologist specialised in hypertension, particularly interested in secondary and resistant hypertension, hypertensive emergencies and, above all, malignant hypertension. Heart failure is also an area of interest, as well as imaging. We are open to all partnerships and collaborations, please contact us if you are interested in these areas.
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- Pr Matthieu LEGRAND After a master's degree in biology, he undertook a PhD entitled "Hemostatic changes in metabolic syndrome, arterial hypertension and heart failure: physiological and pathophysiological approaches", defended in 2013, which earned him a thesis prize from the University of Lorraine. He then completed a 5-year postdoctoral stay in Germany in Professor Wenzel's research team at the Center for Thrombosis and Hemostasis Research at Mainz Medical School, where he was able to demonstrate the major role of immune cells linked to hemostasis in the development of arterial hypertension. In September 2019, he returned to France at UMRS 1116 DCAC and was recruited as a research fellow at INSERM in 2020 with a project focusing on the increased risk of thrombosis during chronic inflammatory bowel disease.
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- Cécile Vindis has a PhD in Biological and Biochemical Sciences and is a Research Director at INSERM (CIC 14136, Toulouse). Her research focuses on the identification of new biomarkers and therapeutic targets for the treatment of coronary pathologies. She was the president of the European COST TransAutophagy network (2016-2020), she is a member of the working group "Atherosclerosis and Vascular Biology" of the European Society of Cardiology and of the Groupe de Réflexion pour la Recherche Cardiovasculaire. In collaboration with the cardiologists and neurologists of the Toulouse University Hospital, Cécile Vindis has set up a new Cardiovascular and Metabolic Biomarkers theme at the Toulouse CIC in order to strengthen Inserm's clinical research.
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- Vincent Dupont obtained his Doctorate in Medicine from the University of Reims Champagne Ardenne, with a double specialization in Nephrology and Medical Intensive Care. Following his Master 2 in Vascular Biology at Université Paris Descartes, he undertook a PhD in Basic Sciences in the "Hemostasis and post-ischemic vascular remodeling" laboratory (HERVI-EA3801). He is currently Visiting Postdoctoral Scientist in Dr Karumanchi's laboratory at Cedars Sinai Medical Center, Los Angeles, CA (USA). He conducts research projects in the field of Nephrology, with a particular interest in endothelial function.
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- Michel Azizi is Professor of Vascular Medicine at the University of Paris. He heads the Hypertension Unit and the Clinical Investigation Centre 1418 at the Georges Pompidou European Hospital, Paris, France.
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- Alexandre Mebazaa is Professor of Anaesthesia-Resuscitation at the UNIVERSITY OF PARIS and is head of the Anesthesia and Intensive Care Department of the Saint Louis-Lariboisière-Fernand Widal Hospital Group. He encourages international exchanges (partnership with Tunisia) and participates in the reception of students in the the European Commission ERASMUS programme. He leads the MASCOT research unit (Cardiovascular MArkers in Stressed COndiTions - UMR-S 942) which is funded by Inserm and the University of Paris, since January 2019.
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- Prof. Eric Vicaut
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- Tahar Chouihed, MD, PhD University Professor and Hospital Practitioner at the Faculty of Medicine of Nancy and CHRU Nancy
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- Bénédicte Stengel, MD, PhD, is a research director at Inserm, the French National Institute for Health and Medical Research, and head of a research team in Clinical Epidemiology at the Centre de Recherche en Epidémiologie et Santé des Populations in Villejuif, France. She contributed to the setting up of the national registry REIN (Réseau Epidémiologie et Information en Néphrologie) with the Agence de la Biomédecine, and coordinates the CKD (Chronic Kidney Disease)-REIN cohort, winner of the call for projects Cohorts-Investissements d'Avenir launched by the French government in 2010. She is co-chair of the CKDopps cohort (CKD outcomes and practice pattern study) and of the iNETCKD network (International Network of CKD Cohorts) of the International Society of Nephrology. Bénédicte Stengel's research focuses on the epidemiology, determinants and biomarkers of the progression and complications of chronic kidney disease, as well as on the evaluation of nephrological practices.
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- Christian Jacquelinet, MD, PhD, HDR is scientific advisor to the medical director of the Agence de la biomédecine (Saint-Denis, France). With a strong clinical background, he is particularly expert in the use of information and communication technologies for translational public health research (epidemiology, evaluation, decision making), based on observational and simulation data. He is responsible for all modelling and simulation studies related to organ allocation policies for transplantation in France. He is the head of the French Registry of End Stage Renal Disease REIN, a shared and comprehensive research infrastructure for renal epidemiology, which provides two use case studies in the inSHARE project (ANR 2013). He is co-coordinator of the CKDREIN/CKDOPPS cohort study (ANR2011). He leads the public health research group of Inserm Unit 1018 (cardio-renal epidemiology, CESP, Villejuif). In the framework of the COST-Action CA-15210: European Collaborative Network on Cross Donation in Kidney Transplantation, he is the chairman of the working group - 4 in charge of the development of an evaluation platform and the dissemination of the results for European decision makers. He is also a partner in the ANR-18-CE40-0019 MATCHES project (Matching Architectures that Connect heterogeneous users and healthcare Efficient Systems) in applied mathematics for graph-based modelling of waiting list management. He is involved in the F-CRIN INI-CRCT (Investigation Network Initiative - Cardiovascular and Renal Clinical Trialists) project on aspects of bioinformatics and clinical research projects embedded in registries.
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- Maurice Laville, nephrologist, is Professor Emeritus of Therapeutics at Claude Bernard University. His main area of interest is chronic kidney disease. He is a member of the INSERM U1060 CarMeN team at Claude Bernard University, of the INI-CRCT research network, and of the steering committee of the CKD-REIN national cohort. Maurice Laville has created and led a health network (TIRCEL) dedicated to early care and care coordination in chronic kidney disease for nearly 20 years. This network has taken care of more than 1500 patients in the Rhône-Alpes region and is currently running an information and screening campaign for CKD in pharmacies. Maurice Laville was Head of the Nephrology Department at the Edouard Herriot Hospital from 1998 to 2006, Head of the Medical Activity Unit from 2006 to 2012, Head of the Nephrology Department at the Lyon Sud Hospital from 2012 to 2017, President of the Nephrology Society from 2011 to 2013, and President of the Kidney Foundation from 2015 to 2017. Since 2005, he has been President of the Association for the Use of the Artificial Kidney in Lyon (AURAL), which provides treatment to nearly 800 patients in the Auvergne Rhône Alpes region.
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- Florence Pinet, obtained her PhD in molecular and cellular pharmacology from the Université Pierre et Marie Curie (Paris) and is Inserm Research Director at the Institut Pasteur in Lille, France. She trained in Paris and has worked in several countries as a student, post-doc and visiting scientist (Switzerland, Japan, USA). She heads an Inserm team dedicated to translational research, whose aim is to find the molecular determinants of cardiac remodeling and heart failure using differential "omics" technologies: proteomics, transcriptomics (miRNAs, lncRNAs). Her research with her team (biologists, cardiologists, statisticians) is devoted to characterizing the omics targets discovered using in vivo, ex vivo and in vitro models of cardiac hypertrophy. She is the author of 140 articles. She is a member of the COST CardioRNA program and has coordinated an ERA-CVD program (LIPCAR-HF) (2016-2020).
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- Emmanuel Montassier is Professor of Therapeutics at the Faculty of Medicine of the University of Nantes, and is an emergency physician at the University Hospital of Nantes. He obtained his PhD in 2014 on alterations of the gut microbiota in patients receiving haematopoietic stem cell transplantation. He specialised in computational microbiology in the laboratory of Prof Daniel Knights at the University of Minnesota. He is also developing clinical trials in the emergency room and the SAMU around therapeutics (pain, treatment of hyperkalaemia). Professor Montassier has published 107 articles with over 2,300 citations.
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- Jean-Noël Trochu, MD, PhD, is Professor of Cardiology and Vascular Diseases, Head of the Thorax Institute*, former Head of the Department of Cardiology and Vascular Diseases at the University Hospital of Nantes, France. He is head of the Heart Failure and Cardiomyopathy Unit of the Thorax Institute, which coordinates several programmes ranging from heart transplantation, total artificial heart and long-term circulatory assistance to patient education and heart failure management programmes. He has been an active member of the ESC Heart Failure Association (HFA) National Heart Failure Societies Committee, an active member of the HFA Heartfailurematters.com Working Group, a former chair of the French Society of Cardiology Heart Failure and Cardiomyopathy Working Group. He is vice-president of research at Nantes University Hospital and director of the clinical research centre at Nantes University Hospital (CIC INSERM 1413). His fundamental research work is closely linked to the clinical departments allowing original integrative approaches in the cardiovascular field: genomics, cell therapy, genetic, pharmacological and physiopathological studies, particularly in the field of heart failure, cardiomyopathies and myocarditis.
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- Bénédicte Sautenet - I am an MCU-PH Therapist - Nephrologist in the Nephrology Department of the CHRU of Tours and a member of the INSERM U1246 SPHERE (methods in patient-centered outcomes & health research) team. My main research interests are the methodology of therapeutic trials in nephrology within the SONG Initiative (Standardised outcomes in nephrology) and arterial hypertension in all areas of nephrology with the PHRC THINK.
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- Nephrologist, Professor of Universities and Hospital Practitioner, Pr Vincent Esnault practices at the Pasteur Hospital in Nice. From fundamental research on vasculitis to his missions at the Collège Universitaire des Enseignants de Néphrologie, including teaching responsibility for the DIU Néphro-Gériatrie, his career path now places him at the head of the Nephrology Dialysis Transplantation Service at the Nice University Hospital. Pr Esnault has chaired the scientific committee of the Mediterranean Interregional Group for Clinical Research and Innovation, and coordinates several national multicentre research programmes in nephrology promoted by the Nice University Hospital.
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- Dr Jean-Sébastien Hulot is Professor of Medicine, Pharmacologist at the University of Paris, France. He is Director of the Clinical Investigation Centre of the Georges Pompidou European Hospital, Paris Hospitals and Research Director of the CARTE (Cardiovascular, Renal and Transplantation) medical university department. A medical cardiologist, he obtained his MD from the Paris Hospitals and his PhD in clinical and experimental pharmacology from the René Descartes University in Paris 5. From 2010 to 2014, he was Associate Professor of Medicine and Cardiology at the Cardiovascular Research Center of the Mount Sinai School of Medicine in New York, USA. He leads an INSERM research team specialising in heart muscle diseases that lead to the development of heart failure. Part of the research programme concerns the development of new therapeutic strategies for patients with heart failure. Another line of research concerns the development of connected tools for faster recognition of abnormalities in heart rhythm or function. He is particularly interested in the forms affecting the youngest subjects (under 50 years old). In particular, he heads a new University Federation labelled APHP/Inserm/University of Paris and dedicated to this subject.
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- Nephrologist working in the Lyon area since 2013, and member of the INI-CRCT network since 2014, I have experience in public, liberal and associative nephrology. I am currently working as a Nephrologist-Head of Department at AURAL (Association for the Use of the Artificial Kidney in the Lyon Region). My professional background is also oriented towards public health and clinical research, with a Master 2 and 2 years of practice in a research department. I have carried out research work in the cardiovascular and renal fields (refractory heart failure, renal artery stenosis, etc.), including the UF-CARE study ("Ultrafiltration in Refractory CArdiorenal Syndrome"), for which I benefited from the precious support of the network.
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- Prof. Sébastien RICHARD Head of the Neurovascular Unit of the Nancy University Hospital and President of the Research and Innovation Department of the Nancy University Hospital. My main research theme is the study of plasma biomarkers in the acute phase of stroke, with a view to constructing new diagnostic tests and identifying new therapeutic targets. We are working on the constitution of a biobank with exhaustive clinical and radiological data in the framework of a major FLAG1 study.
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- Etienne Gayat is Professor of Anaesthesia and Intensive Care at the Université Paris Cité Medical School and has recently been appointed Medical Director of the University Medical Department of Anaesthesia and Intensive Care (DMU PARABOL) of the AP-HP.Nord University Hospital Group. His main field of interest is research on critical conditions and perioperative medicine. He is a team leader in the MASCOT unit of Inserm, whose theme is the development of biomarkers and biotherapies for acute conditions. He has established a collaboration with several teams at Inria (MIND and M3DISIM) around the modelling of physiological signal data such as EEG and blood pressure. He has published more than 240 papers in peer-reviewed journals. He is co-investigator of the FROG-ICU study and co-coordinator of the HELP-MOM study, both involving patients in acute conditions and collection of biological samples. He is the principal investigator of the STOP-OR-NOT and START-OR-NOT trials. He is a member of the editorial board of the journal Intensive Care Medicine.
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- Guillaume Baudry, MD. Cardiologist at the Hospices civils de Lyon. Field of interest in advanced heart failure, mechanical heart assistance and transplantation. I am currently doing a PhD under the supervision of Prof. Rossignol and Prof. Girerd at the University of Lorraine, studying heart-kidney interactions in populations of severe heart failure patients. The objective is to better understand the predictive parameters of renal function degradation as well as the reversibility factors.
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- Sandra Wagner Sandra Wagner holds a PhD from the University of Burgundy in food science and epidemiology. After completing a post-doctoral fellowship at the Centre de Recherche en Epidémiologie et Santé des Populations in Villejuif, she is a researcher in nutritional epidemiology at the Centre d'Investigation Clinique Plurithématique in Nancy. Her research focuses on the impact of nutrition and lifestyle on the development of cardiovascular and/or renal pathologies and on the progression of renal disease. She is also a member of the editorial board of Frontiers in nutrition.
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- Pr. Nicolas GIRERD Cardiologist specialized in heart failure, involved in the filiarization of heart failure activity at Nancy University Hospital (particularly via remote monitoring and the day hospital). Biomathematician and methodologist, involved in numerous trials, including the recently published HYPO-ECMO. Recent particular interest in the implementation of AI in healthcare (e.g. 34538625). Finally, a clinical researcher (300 publications, H-index >30) with a particular interest in acute heart failure, congestion quantification (especially in ultrasound) and biomarkers.
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- Marie-Dominique Devignes, researcher in the CAPSID team - Computational Algorithms for Protein Structures and Interactions.
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- Prof. Ziad A. Massy, M.D., Ph.D. Boulogne / Paris, France Ziad A. Massy is Professor of Nephrology and Head of the Nephrology Department at the University of Versailles Saint Quentin (UVSQ) - Ambroise Paré University Hospital, APHP, Paris, and co-director of the INSERM U-1018 Equipe 5 research team at the UVSQ, Versailles / Villejuif, France Professor Massy is a member of the ERA-EDTA Board and Chair of the ERA-EDTA European Registry and Clinical Governance Affairs. He is an advisor to the EURECAM -ERA-EDTA working group, and the CKD-MBD WG, and a current member and former co-chair of the European Uremic Toxins (EUTox) group.
Map of network members
A wide-ranging collaboration that fosters the exchange of ideas and a diversity of perspectives. The strength of our network of researchers lies in its national and international reach.
